Additional Benefits of Renvela

• High LDL cholesterol is a common and potentially serious risk factor for CKD Stage 5 patients on dialysis.¹
• CKD Stage 5 patients on hemodialysis treated with sevelamer experienced a significant reduction in mean LDL cholesterol (31%) and mean total cholesterol (15%).^2,3

• Renvela has been shown to reduce LDL cholesterol to a mean level of 59.5 mg/dL⁴, which is below the goal of 100mg/dL as recommended by KDOQI guidelines.¹

References

1. National Kidney Foundation. KDOQI clinical practice guidelines for managing dyslipidemias in chronic kidney disease. Am J Kidney Dis. 2003;41(suppl 3):S1-S91

2. Renvela Package Insert, Cambridge, MA: Genzyme Corp; 2007.

3. Renagel Package Insert, Cambridge, MA: Genzyme Corp;2007.

4. Delmez J, Block G, Robertson J, et al. A randomized, double-blind, cross-over design study of sevelamer hydrochloride and sevelamer carbonate in patients on hemodialysis. Clin Nephrol. 2007;68(6):386-391.

Important Treatment Considerations

Renvela® (sevelamer carbonate) and Renagel® (sevelamer hydrochloride) are indicated for the control of serum phosphorus in patients with Chronic Kidney Disease (CKD) on dialysis. Sevelamer is contraindicated in patients with hypophosphatemia or bowel obstruction. Caution should be exercised in patients with dysphagia, swallowing disorders, severe gastrointestinal (GI) motility disorders including severe constipation or major GI tract surgery. Common adverse events reported with sevelamer include vomiting, nausea, diarrhea, dyspepsia, abdominal pain, and constipation. Other events reported include pruritus, rash, fecal impaction, and intestinal obstruction. Drug-drug interactions may occur with some medications and should be taken into consideration when instructing patients how to take sevelamer. Patients should be informed to take sevelamer with meals and to adhere to their prescribed diets. For more information, please see Full Prescribing Information for Renvela, Full Prescribing Information for Renagel or call Genzyme Medical Information at 1-800-847-0069.