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Renvela

Your CKD patient on dialysis —

Our most important BODY OF EVIDENCE

Mechanism of action
Renvela®: a noncalcium, nonmetal phosphate binder that is not absorbed and does not accumulate.2

Efficacy
Renvela has been shown to significantly decrease mean serum phosphorus.2

Dosing
Renvela: the benefits of an effective monotherapy with flexible dosing options in tablet and powder.2

Patients with Medicare Part D and Medicaid prescription drug coverage (dual-eligible) represent the majority of patients on dialysis (44%).1 These patients pay less than $8.25 per fill.3
Certain restrictions may apply.

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Indication

Renvela® (sevelamer carbonate) is used to control phosphorus levels in adults and children 6 years of age and older with chronic kidney disease (CKD) on dialysis.

Renagel® (sevelamer hydrochloride) is indicated for the control of serum phosphorus in patients with chronic kidney disease (CKD) on dialysis.

Important Safety Information

Sevelamer is contraindicated in patients with bowel obstruction and in patients with known hypersensitivity to sevelamer carbonate or sevelamer hydrochloride or to any of the excipients.

Please see additional Important Safety Information.

Please see Full Prescribing Information for Renvela® or Full Prescribing Information for Renagel®

Indication

Renvela® (sevelamer carbonate) is used to control phosphorus levels in adults and children 6 years of age and older with chronic kidney disease (CKD) on dialysis.

Renagel® (sevelamer hydrochloride) is indicated for the control of serum phosphorus in patients with chronic kidney disease (CKD) on dialysis.

Important Safety Information

  • Sevelamer is contraindicated in patients with bowel obstruction and in patients with known hypersensitivity to sevelamer carbonate or sevelamer hydrochloride or to any of the excipients.
  • Caution should be exercised in patients with dysphagia, swallowing disorders, and severe gastrointestinal (GI) motility disorders, including severe constipation or major GI tract surgery.
  • Common adverse events reported with sevelamer include vomiting, nausea, diarrhea, dyspepsia, abdominal pain, flatulence, and constipation. Other events reported include pruritus, rash, fecal impaction and, less commonly, ileus, bowel obstruction, and bowel perforation.
  • Uncommon cases of difficulty swallowing the Renagel or Renvela tablet have been reported. Caution should be exercised in these patients and consideration given to using Renvela suspension in patients with a history of difficulty swallowing.
  • Drug-drug interactions may occur with some medications and should be taken into consideration when instructing patients how to take sevelamer.
  • Serum bicarbonate and chloride levels should be monitored.
  • Follow patients for reduced vitamins D, E, and K (coagulation parameters) and folic acid levels.
  • Patients should be informed to take sevelamer with meals and to adhere to their prescribed diets.

Please see Full Prescribing Information for Renvela® or Full Prescribing Information for Renagel®.
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References:

  1. Data on file, Sanofi US. August 2016.
  2. Renvela [package insert]. Cambridge, MA: Genzyme Corp.
  3. Find Your Level of Extra Help (Part D). The Official U.S. Government Site for Medicare. https://www.medicare.gov/your-medicare-costs/help-paying-costs/extra-help/level-of-extra-help.html. Accessed November 30, 2016.

Important Safety Information

Sevelamer is contraindicated in patients with bowel obstruction and in patients with known hypersensitivity to sevelamer carbonate or sevelamer hydrochloride or to any of the excipients. Click here to read more.