Understand the role of your kidneys
What do kidneys do?
Your kidneys have several functions in the body. They work to remove waste products and extra fluids in your blood. They also play a
role in keeping your bones strong, managing your blood pressure, and balancing phosphorus and calcium.
How is it all related?
When you have chronic kidney disease (CKD) Stage 5, your kidneys can’t do their jobs as
well. Minerals like phosphorus and calcium, as well as other substances like PTH can
become unbalanced. These minerals and substances affect a number of other functions
in the body, like maintaining normal heart, nerve, and muscle function, preserving
healthy bones, and other metabolic processes. That’s why it is important to work with
your healthcare team to keep these minerals and substances in balance, as there can be
a "snowball effect" to many other important functions in your body.
Work with your healthcare team to help keep your mineral levels in a healthy range.
Indication for Renvela and Renagel
Renvela® (sevelamer carbonate) and Renagel® (sevelamer hydrochloride) are indicated for the control of serum phosphorus in patients with chronic kidney disease on dialysis.
Important Safety Information for Renvela and Renagel
- Sevelamer is contraindicated in patients with bowel obstruction.
- Caution should be exercised in patients with dysphagia, swallowing disorders, and
severe gastrointestinal (GI) motility disorders, including severe constipation or
major GI tract surgery.
- Common adverse events reported with sevelamer include vomiting, nausea, diarrhea,
dyspepsia, abdominal pain, flatulence, and constipation. Other events reported include
pruritus, rash, fecal impaction and, less commonly, ileus, bowel obstruction, and
- Uncommon cases of difficulty swallowing the Renagel (sevelamer hydrochloride) or Renvela® (sevelamer carbonate)
tablet have been reported. Caution should be exercised in these patients and consideration
given to using Renvela® (sevelamer carbonate) suspension in patients with a history
of difficulty swallowing.
- Drug-drug interactions may occur with some medications and should be taken into
consideration when instructing patients how to take sevelamer.
- Serum bicarbonate and chloride levels should be monitored.
- Follow patients for reduced vitamins D, E, and K (coagulation parameters) and folic
- Patients should be informed to take sevelamer with meals and to adhere to their
Please see full Prescribing Information for Renvela (PDF) or full Prescribing Information for Renagel (PDF).
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The health information contained herein is provided for general education purposes only. Your healthcare professional is
the single best source of information regarding your health. Please consult your healthcare professional if you have any
questions about your health or treatment.